Box 1. Study definitions

Region	Eastern Europe	Belarus, Estonia, Georgia, Latvia, Lithuania, Poland, Romania, Ukraine, Russia
Delayed diagnosis		Delayed diagnosis was defined as duration of TB symptoms (cough, weight-loss or fever) for ≥ 1 month before TB diagnosis
TB diagnosis	Definite	Positive culture or PCR (Xpert) for Mtb (in sputum smear or other specimen)
	Probable	Acid fast bacilli or granulomatous inflammation in sputum smear or tissue biopsy and other specimens (e.g., CSF, Pleural fluid)
	Presumptive	A patient who presents with symptoms or signs suggestive of TB where TB treatment is initiated and not subsequently stopped because the TB diagnosis was ruled out
TB location	Pulmonary	TB localised to the lungs, larynx, or tracheobronchial tree
	Extrapulmonary	just one extra-pulmonary site was identified
	Disseminated	Either of the following: (i) TB documented in at least two organ systems (one of which could be lungs) (ii) miliary TB, or (iii) isolation of Mtb from blood or bone marrow
TB drug resistance	MDR	Mtb resistant to both rifamycin and isoniazid
AIDS		Clinical AIDS criteria (ref: 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults)