Table 2.
Odds ratios of ANRIL tag SNPs for CAD by multivariable logistic regression analysis
| SNP | Model | Cases (n) | Controls (n) | Adjusted OR (95% CI) | P value | |
|---|---|---|---|---|---|---|
| rs1004638 | Genotype | TT (Ref.) | 27 | 68 | 1 | |
| AT | 206 | 208 | 2.13 (1.34–3.40) | 0.001 | ||
| AA | 268 | 225 | 2.50 (1.58–3.95) | < 0.001 | ||
| AT + AA | 474 | 433 | 2.32 (1.49–3.62) | < 0.001 | ||
| Ptrend | 0.008 | |||||
| Allele | T (Ref.) | 260 | 344 | 1 | ||
| A | 742 | 658 | 1.39 (1.15–1.69) | < 0.001 | ||
| rs1333048 | Genotype | AA (Ref.) | 104 | 141 | 1 | |
| AC | 249 | 259 | 1.38 (1.01–1.88) | 0.044 | ||
| CC | 147 | 97 | 2.02 (1.40–2.91) | < 0.001 | ||
| AC + CC | 396 | 356 | 1.56 (1.16–2.09) | 0.003 | ||
| Ptrend | 0.001 | |||||
| Allele | A (Ref.) | 457 | 541 | 1 | ||
| C | 543 | 453 | 1.40 (1.17–1.67) | < 0.001 | ||
| rs1333050 | Genotype | CC (Ref.) | 101 | 124 | 1 | |
| CT | 259 | 265 | 1.21 (0.88–1.66) | 0.242 | ||
| TT | 142 | 109 | 1.58 (1.09–2.28) | 0.015 | ||
| CT + TT | 401 | 374 | 1.32 (0.97–1.78) | 0.074 | ||
| Ptrend | 0.027 | |||||
| Allele | C (Ref.) | 461 | 513 | 1 | ||
| T | 541 | 483 | 1.24 (1.04–1.48) | 0.018 | ||
Ref.: reference variable; CAD: coronary artery disease; OR: odds ratio; CI: confidence interval. Trend test was examined by χ2 test (linear-by-linear association)