Table 3.
Association of gene dosage of ANRIL tag SNPs with CAD severity
| SNP | Genotype/p-value | CAD, n (%) | Criminal Vessels, n (%) | Gensini scores | |||
|---|---|---|---|---|---|---|---|
| Yes | No | Multi-VD | 1-VD | n | Mean ± SD | ||
| rs1004638 | TT | 27 (28.42) | 68 (71.58) | 15 (55.56) | 12 (44.44) | 27 | 37.17 ± 34.28 |
| AT | 206 (49.76) | 208 (50.24) | 131 (63.59) | 75 (36.41) | 205 | 37.36 ± 32.62 | |
| AA | 268 (54.36) | 225 (45.64) | 183 (68.28) | 85 (31.72) | 268 | 41.93 ± 34.08 | |
| P | < 0.001 | 0.296 | 0.313 | ||||
| rs1333048 | AA | 104 (42.45) | 141 (57.55) | 63 (60.58) | 41 (39.42) | 104 | 34.47 ± 30.52 |
| AC | 249 (49.02) | 259 (50.98) | 158 (63.45) | 91 (36.55) | 248 | 36.69 ± 32.78 | |
| CC | 147 (60.25) | 97 (39.75) | 107 (72.79) | 40 (27.21) | 147 | 49.01 ± 35.16 | |
| P | < 0.001 | 0.027 | < 0.001 | ||||
| rs1333050 | CC | 101 (44.89) | 124 (55.11) | 66 (65.35) | 35 (34.65) | 101 | 36.96 ± 32.39 |
| CT | 259 (49.43) | 265 (50.57) | 162 (62.55) | 97 (37.45) | 258 | 36.11 ± 31.51 | |
| TT | 142 (56.57) | 109 (43.43) | 102 (71.83) | 40 (28.17) | 142 | 48.61 ± 36.24 | |
| P | 0.034 | 0.172 | 0.001 | ||||
CAD: coronary artery disease; Multi-VD: multi-vessel disease; 1-VD: 1-vessel disease. SD: standard deviation