Figure 1.

Linkage disequilibrium structure and distribution of sequence variants in the CCKAR. This diagram shows the linkage disequilibrium structure of genomic region at Chromosome 4: 73202000-73210500. This region covers the whole CCKAR gene and upstream 1.4 kb region from transcription start site. The white points in the gene structure diagram represent 124 variants. The other two variants were excluded from linkage disequilibrium analysis due to minor allele frequencies less than 0.05. Those shown on the gene structure diagram are 33 tag SNPs. The bold black line indicates the region where most (8/11) of significantly associated tag SNPs were distributed. Haplotype blocks are outlined in black triangles on the linkage disequilibrium structure graph.