Figure 2.

Structure of CDK-14. A, Schematic diagrams of CDK-14 isoforms. The cdk-14 gene encodes three isoforms: CDK-14a, CDK-14b, and CDK-14c. Boxes indicate exons, and lines indicate introns and untranslated regions. Blue boxes represent the kinase domain. B, Structure of CDK-14 isoforms. Schematic diagrams of CDK-14 isoforms are shown. The blue boxes represent the kinase domain. C, Sequence alignments of human CDK14 and C. elegans CDK-14 in the kinase domain. Identical residues are highlighted in gray. The conserved lysine residue (orange) required for kinase activity is shown.