Figure 4.

EGL-20/Wnt and MIG-1/Fz are required for axon regeneration. A, MIG-1/Fz-mediated signaling pathways. MIG-1 mediates CWN-2 and EGL-20 signaling to regulate synapse formation and neurite outgrowth, respectively. Schematic diagrams of MIG-1, CWN-1, CWN-2, and EGL-20 are shown. The transmembrane region and signal sequence are indicated by gray and black boxes, respectively. The e1787 and n585 mutation sites are indicated. The regions deleted in ok546 and ok895 are indicated by black bars. B, Percentages of axons that initiated regeneration 24 h after laser surgery in young adults. The number of axons examined is shown. Error bars indicate 95% confidence intervals. *p < 0.05, **p < 0.01, as determined by Fisher's exact test. NS, Not significant.