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Gene-level germline rare, deleterious variant (RDV) burden on ATM in all study cohorts.
| Discovery cohort | Validation cohort | Combined cohort | ||||
|---|---|---|---|---|---|---|
| Case (513) |
Control (3423) |
Case (472) |
Control (3417) |
Case (989) |
Control (6981) |
|
| ATM Gene | ||||||
| # Variants | 4 | 7 | 6 | 8 | 9 | 14 |
| # Unique individuals | 5 (0.97%) |
8 (0.23%) |
7 (1.48%) |
9 (0.26%) |
12 (1.21%) |
17 (0.24%) |
| OR (p-val) [95% CI] |
4.05 (0.02) [1.3–11.9] |
5.50 (1.37e-03) [2.0–14.4] |
4.58 (1.66e-04) [2.2–9.5] |
|||
