Table 3.
Diffusion tensor tractography. Linear regression models of the relationship between minimum and maximum glucose (mmol/L) on each day of life and diffusion tensor tractography metrics, including fractional anisotropy (FA) and mean diffusivity (MD). All models are adjusted for postmenstrual age at time of MRI, 5-minute Apgar scores, and umbilical artery pH. Minimum glucose models adjust for maximum glucose, and vice versa. Standardized beta coefficients (β) are included. Significant sharpened q-values are marked with an asterisk.
| FA | β | q-value | MD (10−5 mm2/s) | β | q-value | |
|---|---|---|---|---|---|---|
| Corticospinal tract | ||||||
| Minimum glucose day 1 | 0.0044 | 0.17 | 0.10 | −1.83 | −0.23 | 0.08 |
| Maximum glucose day 1 | −0.0003 | −0.03 | 0.60 | 0.74 | −0.26 | 0.02* |
| Optic radiation | ||||||
| Minimum glucose day 1 | 0.0043 | 0.15 | 0.11 | −0.10 | 0.01 | 0.30 |
| Maximum glucose day 1 | −0.0017 | −0.17 | 0.12 | −1.67 | −0.37 | 0.001* |
| Corticospinal tract | ||||||
| Minimum glucose day 2 | 0.0046 | 0.28 | 0.10 | −1.66 | −0.33 | 0.10 |
| Maximum glucose day 2 | −0.0041 | −0.49 | 0.008* | 0.42 | 0.16 | 0.43 |
| Optic radiation | ||||||
| Minimum glucose day 2 | 0.0068 | 0.37 | 0.08 | −4.60 | −0.57 | 0.02* |
| Maximum glucose day 2 | −0.0067 | −0.69 | 0.001* | 0.85 | 0.20 | 0.26 |
| Corticospinal tract | ||||||
| Minimum glucose day 3 | 0.0013 | 0.07 | 0.24 | −1.08 | −0.17 | 0.17 |
| Maximum glucose day 3 | −0.0014 | −0.13 | 0.47 | −0.23 | −0.07 | 0.60 |
| Optic radiation | ||||||
| Minimum glucose day 3 | 0.0075 | 0.34 | 0.10 | −3.80 | −0.39 | 0.09 |
| Maximum glucose day 3 | −0.0068 | −0.54 | 0.008* | 0.31 | −0.06 | 0.60 |