Table 1.
Description of L-Measure outputs
| Core function (brief description) | Relevant statistics to consider | Reasoning behind the chosen statistic |
|---|---|---|
| N_bifs (number of bifurcations) | Total_sum | Returns the total number of bifurcations |
| N_branch (number of branches) | Total_sum | Returns the total number of branches |
| Width (neuronal width) | L-Measure returns the same value for Min, Max, and Ave | Horizontal extent (x-coordinate) containing 95% of all tracing points |
| Height (neuronal height) | L-Measure returns the same value for Min, Max, and Ave | Vertical extent (y-coordinate) containing 95% of all tracing points |
| Depth (neuronal depth) | L-Measure returns the same value for Min, Max, and Ave | Depth (z-coordinate) containing 95% of all tracing points |
| Length (total arborization length) | Total_sum | Returns the total length summed across all compartments |
| EucDistance (maximum Euclidean distance from soma to the tips) | Ave and max are relevant, we used Max | Maximum straight distance encompassing the whole neuron |
| PathDistance (path distance of a compartment) | Ave and max are relevant, we used Max | Maximum geodesic distance from soma to tips |
| Branch_Order (order of the branch with respect to the soma) | Ave and max are relevant, we used Max | Maximum number of bifurcations from soma to tips |
| Contraction (ratio between Euclidean distance of a branch and its path length) | Ave | Average tortuosity across all branches |
| Fragmentation (total number of compartments that constitute a branch between two bifurcation points) | All are relevant, we used Total_sum | Total number of compartments from all of the branches |
| Partition_asymmetry (average over all bifurcations of sub-trees) | Ave | Topological tree asymmetry measured from all bifurcation points |
| Bif_ampl_local (angle between the first two bifurcation compartments) | All are relevant, we used Ave | Average over all bifurcations of the angle between the first two daughter compartments |
| Bif_ampl_remote (angle between, current plane of bifurcation and previous plane of bifurcation) | All are relevant, we used Ave | Average over all bifurcations of the angle between the following bifurcations or tips |
| Fractal_Dim (slope of linear fit of regression line obtained from the plot of path vs. Euclidean distances) | All are relevant, we used Ave | Average space occupancy measured from all branches |