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Chronological lifespan extension due to an sch9Δ mutation is reversed by an ira2 mutation. Wild type (BY4741 × BY4742) and isogenic sch9Δ × sch9Δ (PPY745), ira2 × ira2 (PPY737), and sch9Δ ira2 × sch9Δ ira2 (PPY741) mutant strains were grown in YPR media for 30 days after cultures reached saturation. Percent survival was calculated using colony forming assay at the indicated time points. Errors bars represent the standard deviation of the results from two independent experiments.
