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. 2021 Oct 5;10(12):4. doi: 10.1167/tvst.10.12.4

Table 2.

Median Time to Progression and Hit-Rate at Three Specificity Levels for Series Truncated at 10 Tests (the Minimum Required for Inclusion)

Specificity
Model 97.5% 95% 90%
Median time to progression (years [95% CIs]) (10 tests)
 Hi-linear 6.5 [6.2, 6.8] 5.7 [5.4, 5.9] 5.1 [4.9, 5.3]
 Hi-censored 6.2 [6.0, 6.5] 5.6 [5.4, 5.9] 5.1 [4.9, 5.2]
 Hi-HSK 6.3 [6.0, 6.6] 5.6 [5.3, 5.8] 5.0 [4.8, 5.2]
 Simple linear 11 [10.7, 11.4] 9.3 [9.1, 9.7] 7.5 [7.2, 7.8]
 PoPLR (p-value) 10.1 [9.8, 10.4] 8.6 [8.3, 8.9] 6.9 [6.7, 7.2]
 PoPLR (S) 7.4 [7.1, 7.7] 6.7 [6.4, 6.9] 5.8 [5.6, 6]
Hit-rate (% [95% CIs]) (10 tests)
 Hi-linear 53 [51, 53] 57 [55, 57] 61 [59, 61]
 Hi-censored 54 [51, 53] 57 [55, 57] 61 [59, 61]
 Hi-HSK 52 [51, 52] 55 [54, 55] 59 [57, 59]
 Simple linear 32 [29, 32] 37 [35, 37] 45 [43, 45]
 PoPLR (p-value) 35 [33, 36] 41 [39, 41] 50 [47, 49]
 PoPLR (S) 49 [47, 49] 52 [50, 52] 56 [55, 56]

Hi = Hierarchical; HSK = Heteroskedastic.

The 95% confidence intervals (CIs) were obtained from the Kaplan Meier estimator for the median time to progression and via bootstrap for the hit-rate.