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. Author manuscript; available in PMC: 2021 Oct 7.
Published in final edited form as: Science. 2021 Feb 26;371(6532):eabb1625. doi: 10.1126/science.abb1625

Fig. 2. Zone 1 and zone 3 compartments contract during normal homeostasis.

Fig. 2.

(A) For each of the lineage tracing experiments in this figure, we measured the proportion of total lobular area covered by Tomato as a proxy measure for hepatocyte repopulation (quantified on the right). Over 6 and 12 months, the percent area labeled by Gls2CreER decreased. (B) Over 6 and 12 months, the percent area labeled by Cyp1a2-CreER increased. (C) Over 6 and 12 months, the percent area labeled by GS-CreER did not change. (D) Over 6 months, the percent area labeled by Arg1.1CreER did not change, but after 12 months, the percent area increased. (E) Over 6 and 12 months, the percent area labeled by Arg1.2-CreER increased. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant. Error bars indicate standard deviation (SD).