Table 3.
Characteristics of participants according to immunoglobulin A response to MAP.
| IgA—MAP0210c | |||||
|---|---|---|---|---|---|
| Q1: | Q2: | Q3: | Q4: | p-value | |
| n = 77 | n = 89 | n = 105 | n = 101 | ||
| Female sex, n [%] | 44 [57.1] | 58 [65.2] | 62 [59.0] | 61 [60.4] | 0.737 |
| Age, mean [SD] | 45.1 [16.1] | 47.2 [14.8] | 46.6 [15.6] | 48.9 [14.9] | 0.082 |
| Age at diagnosis, n [%] | |||||
| ≤16 years old | 14 [18.2] | 12 [13.5] | 15 [14.3] | 9 [8.9] | 0.255 |
| 17–40 years old | 53 [68.8] | 58 [65.2] | 62 [59.0] | 69 [68.3] | |
| >40 years old | 10 [13.0] | 19 [21.3] | 28 [26.7] | 23 [22.8] | |
| Smoking status; ever, n [%] | 34 [45.9] | 52 [63.4] | 65 [64.4] | 71 [73.2] | 0.004 |
| Disease duration, mean [SD] | 17.8 [10.9] | 17.0 [10.1] | 16.3 [10.7] | 17.2 [10.6] | 0.366 |
| Disease location [CD], n [%] | |||||
| Ileum | 6 [23.1] | 9 [19.6] | 15 [30.6] | 16 [32.7] | 0.465 |
| Colon | 5 [19.2] | 11 [23.9] | 13 [26.5] | 15 [30.6] | |
| Ileum and colon | 15 [57.7] | 26 [56.5] | 21 [42.9] | 18 [36.7] | |
| Disease extent [UC], n [%] | |||||
| Proctitis | 3 [6.8] | 6 [15.8] | 4 [8.9] | 5 [11.4] | 0.889 |
| Left-sided colitis | 15 [34.1] | 10 [26.3] | 13 [28.9] | 14 [31.8] | |
| Extensive colitis | 26 [59.1] | 22 [57.9] | 28 [62.2] | 25 [56.8] | |
| Ever need for: | |||||
| Biologic treatment, n [%] | 26 [33.8] | 31 [34.8] | 47 [45.6] | 39 [39.0] | 0.329 |
| Surgical intervention, n [%] | 20 [26.0] | 35 [39.3] | 34 [32.4] | 31 [30.7] | 0.316 |
| IgA—MAP2609 | |||||
| Q1: | Q2: | Q3: | Q4: | p-value | |
| n = 94 | n = 102 | n = 119 | n = 149 | ||
| Female sex, n [%] | 54 [57.4] | 60 [58.0] | 68 [57.1] | 77 [51.7] | 0.661 |
| Age, mean [SD] | 45.8 [16.9] | 46.1 [13.7] | 48.0 [15.2] | 51.4 [14.6] | 0.006 |
| Age at diagnosis, n [%] | |||||
| ≤16 years old | 13 [13.8] | 12 [11.8] | 17 [14.3] | 11 [7.4] | 0.408 |
| 17–40 years old | 61 [64.9] | 72 [70.6] | 74 [62.2] | 98 [66.2] | |
| >40 years old | 20 [21.3] | 18 [17.6] | 28 [23.5] | 39 [26.4] | |
| Smoking status; ever, n [%] | 46 [55.4] | 57 [58.8] | 71 [62.3] | 98 [67.1] | 0.311 |
| Disease duration, mean [SD] | 16.1 [9.9] | 17.1 [10.5] | 16.5 [10.1] | 18.6 [10.7] | 0.408 |
| Disease location [CD], n [%] | |||||
| Ileum | 19 [35.2] | 19 [39.6] | 13 [22.0] | 24 [28.2] | 0.333 |
| Colon | 11 [20.4] | 7 [14.6] | 14 [23.7] | 24 [28.2] | |
| Ileum and colon | 24 [44.4] | 22 [45.8] | 32 [54.2] | 37 [43.5] | |
| Disease extent [UC], n [%] | |||||
| Proctitis | 0 [0.0] | 4 [9.3] | 11 [22.4] | 4 [6.8] | 0.003 |
| Left-sided colitis | 17 [48.6] | 9 [20.9] | 18 [36.7] | 23 [39.0] | |
| Extensive colitis | 18 [51.4] | 30 [69.8] | 20 [40.8] | 32 [54.2] | |
| Ever need for: | |||||
| Biologic treatment, n [%] | 24 [26.1] | 34 [33.3] | 51 [42.9] | 67 [45.0] | 0.013 |
| Surgical intervention, n [%] | 33 [35.1] | 30 [29.4] | 40 [33.6] | 61 [40.9] | 0.287 |
Ig, immunoglobulin; SD, standard deviation; CD, Crohn’s disease; UC, ulcerative colitis.