Table 1.
Demographic and Clinical Characteristics of Participants With Current, Previous, and Never INSTI Use, DC Cohort and Johns Hopkins HIV Clinical Cohort, 2017–2019
| Currently on INSTI | Previously on INSTI | Never on INSTI | ||
|---|---|---|---|---|
| No. (Row %) | No. (Row %) | No. (Row %) | P | |
| Overall (n = 9558) | 6839 (71.5) | 754 (7.9) | 1965 (20.6) | — |
| Clinic location | <.0001 | |||
| Baltimore—Hopkins (n = 2302) | 1796 (78.0) | 219 (9.5) | 287 (12.5) | |
| DC (n = 7256) | 5043 (69.5) | 535 (7.4) | 1678 (23.1) | |
| Age, y | <.0001 | |||
| 18–24 (n = 206) | 167 (81.1) | 11 (5.3) | 28 (13.6) | |
| 25–39 (n = 1713) | 1222 (71.3) | 115 (6.7) | 376 (21.9) | |
| 40–49 (n = 1860) | 1269 (68.2) | 151 (8.1) | 440 (23.7) | |
| 50+ (n = 5779) | 4181 (72.3) | 477 (8.3) | 1121 (19.4) | |
| Gender and sexual risk behaviora | .0017 | |||
| Cisgender male—MSM (n = 3376) | 2390 (70.8) | 269 (8.0) | 717 (21.2) | |
| Cisgender male—heterosexual (n = 3165) | 2297 (72.6) | 229 (7.2) | 639 (20.2) | |
| Cisgender female (n = 2856) | 2059 (72.1) | 239 (8.4) | 558 (19.5) | |
| Transgender female (n = 151) | 87 (57.6) | 16 (10.6) | 48 (31.8) | |
| Transgender male (n = 10) | 6 (60) | 1 (10) | 3 (30) | |
| Race/ethnicity | .29 | |||
| Non-Hispanic Black (n = 7386) | 5294 (71.7) | 589 (8.0) | 1503 (20.3) | |
| Non-Hispanic White (n = 1332) | 952 (71.5) | 104 (7.8) | 276 (20.7) | |
| Hispanic (n = 514) | 377 (73.3) | 36 (7.0) | 101 (19.7) | |
| Other/unknown (n = 326) | 216 (66.2) | 25 (7.7) | 85 (26.1) | |
| Insurance statusa | <.0001 | |||
| Public (n = 5956) | 4374 (73.4) | 428 (7.2) | 1154 (19.4) | |
| Private (n = 3175) | 2151 (67.7) | 301 (9.5) | 723 (22.8) | |
| No insurance (n = 147) | 111 (75.5) | 2 (1.4) | 34 (23.1) | |
| Insurance type unknown (n = 280) | 203 (72.5) | 23 (8.2) | 54 (19.3) | |
| Last recorded HIV viral load, copies/mL | .030 | |||
| <200 | 5383 (78.7) | 565 (74.9) | 1537 (78.2) | |
| 200+ | 606 (8.9) | 92 (12.2) | 170 (8.7) | |
| Unknown | 850 (12.4) | 97 (12.9) | 258 (13.1) | |
| Currently on INSTI (n = 6839) | Previously on INSTI (n = 754) | Never on INSTI (n = 1965) | ||
| No. (Col %) | No. (Col %) | No. (Col %) | P | |
| Current alcohol abuse | 1614 (23.6) | 156 (20.7) | 412 (21.0) | .017 |
| Current smoking | 2658 (38.9) | 263 (34.9) | 738 (37.6) | .078 |
| History of injection drug use | 970 (14.2) | 119 (15.8) | 207 (10.5) | <.0001 |
| Years since first HIV care visit at clinic, median (IQR)b | 9.4 (5.3–14.3) | 9.6 (5.6–15.4) | 9.4 (6.3–13.3) | .19 |
| HIV drug resistance mutationsa | ||||
| Major NRTI mutation present | 1303 (19.1) | 156 (20.7) | 165 (8.4) | <.0001 |
| Major NNRTI mutation present | 1258 (18.4) | 124 (16.4) | 183 (9.3) | <.0001 |
| Major PI mutation present | 569 (8.3) | 53 (7.0) | 80 (4.1) | <.0001 |
| Major INSTI mutation present | 101 (1.5) | 28 (3.7) | 22 (1.1) | <.0001 |
Abbreviations: INSTI, integrase strand transfer inhibitor; IQR, interquartile range; MSM, men who have sex with men; NNRTI, non-nucleoside reverse transcriptase inhibitor; NRTI, nucleoside reverse transcriptase inhibitor; PI, protease inhibitor.
aSee Supplementary Table 1 for definitions.
bThere were 183 missing values for years since first HIV care visit.