Table 1.
Demographics and Clinical Outcomes of the Included Cohorts
| Characteristic | Cohort 1 [2] (n = 40) | Cohort 2 [3] (n = 66) |
|---|---|---|
| Age, y, median (IQR) | 53.5 (47.0 to 62.3) | 58 (51.5 to 67.0) |
| White race | 28 (70.0) | 57 (86.4) |
| Sex male | 17 (42.5) | 29 (43.9) |
| Transfusion within 24 h of hospital admission | 38 (95.0) | 62 (93.9) |
| Study-specific APACHE scorea | ||
| Mean | 26.9 | 77.56 |
| Median (IQR) | 29.0 (23.5 to 31.3) | 71.5 (51.5 to 95.8) |
| Standardized APACHE score | ||
| Mean | 0 | 0 |
| Median (IQR) | 0.28 (−0.46 to 0.58) | -0.21 (−0.91 to 0.64) |
| Mechanically ventilated | 29 (72.5) | 66 (100) |
| Days inpatient before enrollment, mean | 0.25 | 3.15 |
| Baseline ALCb | ||
| Mean | NA | 911.52 |
| Median (IQR) | NA | 800 (500 to 1100) |
| Number still hospitalized at day 28 | 8 (20) | 11 (17) |
| Number who died by day 28 | 4 (10) | 10 (15) |
Data are No. (%) except where indicated.
Abbreviations: ALC, absolute lymphocyte count; APACHE, Acute Physiology and Chronic Health Evaluation; IQR, interquartile range.
aAPACHE II scores used in cohort 1, APACHE III scores used in cohort 2. A standardized APACHE score was created for this study so that the APACHE scores in each cohort were rescaled to have a mean of zero and a standard deviation of 1. The range for APACHE II scores is 0–71; the range for APACHE III scores is 0–299.
bALC data only available for cohort 2.