Table 2.

Association Between CMV Reactivation and Clinical Outcomes at 28 Days^a

CMV Measure	Hospitalized or Died by Day 28b	Ventilator-Free Daysc	ICU-Free Daysc	Hospital-Free Daysc
CMV reactivation any level	3.1 (1.2 to 8.6) P = .021	−3.3 (−6.7 to .1) P = .063	−4.1 (−7.3 to −.8) P = .016	−4.9 (−8.0 to −1.9) P = .002*
CMV reactivation > 100 IU/mL	6.0 (2.1 to 18.7) P = .001*	−5.2 (−9.0 to −1.4) P = .009*	−6.0 (−9.6 to −2.3) P = .002*	−6.3 (−9.7 to −2.9) P = .0005*
CMV reactivation >1000 IU/mL	5.6 (1.6 to 23.7) P = .011	−6.3 (−11.1 to −1.5) P = .012	−7.5 (−12.1 to −2.9) P = .002*	−6.5 (−10.9 to −2.1) P = .005*
Average AUC CMV load, log IU/mL	2.0 (1.0 to 4.0) P = .049	−1.6 (−4.0 to .8) P = .190	−2.5 (−4.8 to −.2) P = .032	−2.9 (−5.0 to −.7) P = .011
Peak CMV load, log IU/mL	1.7 (1.2 to 2.5) P = .005*	−1.5 (−2.8 to −.3) P = .019	−1.9 (−3.1 to −.7) P = .003*	−2.1 (−3.2 to −1.0) P = .0004*

P values in bold represent values that were statistically significant.

Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; AUC, area under the curve; CI, confidence interval; CMV, cytomegalovirus; ICU, intensive care unit.

*P values remained statistically significant (P < .05) after Bonferroni adjustment.

^aAfter adjustment for baseline transfusion status and a standardized score created from APACHE II and APACHE III scores used in the individual studies, confounders found relevant in backward stepwise regression.

^bEstimates represent odds ratios and associated 95% CIs.

^cEstimates represent the difference in mean days and associated 95% CIs.