Figure 10.

Example LCP-TF electrode human intraoperative recording to study motor responses. (A) A 244-ch LCP-TF electrode array recorded neural activity during voluntary finger movement from the ‘hand-knob’ region of the motor cortex of a patient undergoing tumor resection. The electrode impedance data for this array can be found in supplemental figure 4. (B) The participant performed a finger movement task following visually presented cues. The finger kinematics were recorded using a data glove. (C) Normalized high gamma (HG) responses (70–150 Hz; maximum values from −500 ms to 500 ms at movement onset) revealed spatial features of the finger movements focused on the top right corner of the array. (D) A statistical analysis (one-sided permutation test) was performed to determine the channels with significant HG responses during movement onset relative to baseline (p < 0.05, FDR corrected). The blue box indicates the 8 × 8 area of the array that is the focus for panel E. (E) Spatial maps of normalized high-gamma responses separated by finger types during movement. 0 s indicates the onset of finger movement from the glove data. (F) Finger flexion decoding using a linear classification scheme (leave-one-out cross-validation) obtained 61% and 96% classification accuracies for five-finger and three-finger decoders, respectively.