Figure 9.

Example LCP-TF electrode human intraoperative recording to study speech and language. (A) A 244-channel LCP-TF electrode array (bottom) recorded auditory responses from the posterior superior temporal gyrus (pSTG—top) in a patient undergoing treatment for pharmacologically resistant epilepsy. The patient was asleep during the auditory stimulus (words and non-words) presentation. The in vivo electrode impedance data can be found in supplemental figure 3. (B) Spectrograms for the local field from each channel (right) show auditory responses on selective channels. These responses were mainly found in the high gamma (HG) frequency range (70–150 Hz), shown to be a correlate of multi-unit neuronal firing. The red star denoted the high impedance channel. (C) The red channels exhibit significant high-gamma responses during auditory onset relative to baseline (one-sided permutation test, p < 0.05, FDR corrected). (D) Normalized HG time-series heat maps show the spatial detail of the auditory response.