Fig 4. Genes with consistent upregulation are enriched in interferon-related categories and neutrophil activation.

a) Manhattan plot where each dot is a gene deregulated in DS, the level of opacity indicates the pseudo t-score. The top 500 DE genes are plotted in bigger size. b) Distribution of pseudo-t-scores. The consistently up-regulated and down-regulated genes are in black. c) Barplot showing the average pseudo-t-score in HSA21 genes, their primary, secondary, tertiary interactors, and the other proteins of the network d) Gene ontology analysis for the genes with high absolute pseudo-t-score (in black in b).