Fig 5. DS genes form a modular network.

DS network where each node is a gene found DE in at least 4 comparisons. Edges represent co-DE events between genes colored based on the size of the co-DE cluster. Edge thickness is proportional to the number of occurrences of co-DE and the STRINGdb score. We did not plot the edges corresponding to co-DE pairs found in less than 4 comparisons). Size is proportional to the log₂ of the occurrences of DE. Genes encoded by HSA21 are depicted with a square, non-HSA21 with a circle. The significant enrichments for each module are indicated with boxes of different colors.