Fig 7. Disease association in DS genes.

a) Boxplots comparing the mean disease pleiotropic indexes of 1000 permutation of 500 random genes compared to the mean disease pleiotropic index of the top 500 genes. b) Heatmap showing the percentage of disease classes of the genes belonging to the three clusters. Genes with high pleiotropic scores are associated with different disease classes. c) Boxplots comparing the mean similarity score of 1000 permutation of 12–13 random genes compared to the mean similarity score of the genes belonging to our three co-DE clusters. Similarity was assessed (from top to bottom panel) using the GOs biological processes (BP), molecular function (MF), cell component (CC) or disease ontology (DO). d) Heatmap showing the GDA’ scores of genes belonging to the three clusters.