Figure 3. ∣. Meningeal γδ17 T cells regulate anxiety-like behavior.

a_i, Cumulative movement of wild type (WT) and γδ T cell-deficient (Tcrd^−/−) mice in the elevated plus maze. a_ii, Percentage time spent in the open arms of the maze. WT (n = 18); Tcrd^−/− (n = 20). Pool of two independent experiments. b_i, Cumulated movement of WT and Tcrd^−/− animals in the open field test. b_ii, Total ambulatory distance in the arena. b_iii, Percentage time spent in the center of the arena. WT (n = 8); Tcrd^−/− (n = 8). c, WT mice were injected (i.c.m.) with 2.5 μg of anti-TCR γδ or isotype control and three days later were assessed in the elevated plus maze. c_i, Cumulated movement of isotype control– or anti-TCR γδ–injected mice. c_ii, Percentage time spent in the open arms of the maze. Isotype control (n = 15); anti-TCR γδ (n = 16). Results pooled from two independent experiments. d, WT mice were injected anti-TCR γδ or isotype control and three days later were assessed in the open field task. d_i, Cumulative movement in the open field arena. d_ii, Total distance traveled. d_iii, Percentage time spent in the center of the arena. Isotype control (n = 16); anti-TCR γδ (n = 17). Data were pooled of two independent experiment. a-d, Data are expressed as mean ± s.e.m. and each dot symbol represents individual mouse. Unpaired two-tailed t test.