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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Immunol. 2021 Sep 3;207(7):1871–1881. doi: 10.4049/jimmunol.2001142

Figure 1. The magnitude and the kinetics of the cytokine storm depends on the sepsis severity.

Figure 1.

A) Experimental Design. Mice underwent sham or CLP surgery (1 or 2 cecal punctures to induce moderate or severe sepsis, respectively) and serum was collected at the indicated timepoints after surgery. B) Survival and C) weight loss were monitored for 72 h after surgery. D) Detection of indicated analytes in the serum after surgery. Parentheses indicate level of detection for a given cytokine/chemokine. E) Summary data of analyte levels (fold change to sham controls) at 12 (left) and 24 (right) hours after sepsis induction. Data are representative of 3 independent experiments with at least 3 mice per group. Error bars represent the standard error of the mean.