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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Immunol. 2021 Sep 3;207(7):1871–1881. doi: 10.4049/jimmunol.2001142

Figure 7. The severity of sepsis governs the extent of numerical loss of tumor-infiltrating CD8 T cells.

Figure 7.

A) Experimental Design. LCMV-immune P14 memory CD8 T cell mice received an s.c. injection of B16 melanoma cells in the hind flank. Mice underwent sham or CLP surgery (moderate or severe) 15 days later. After 2 days, mice received an i.v. injection of anti-CD45.2 mAb and tumors were collected 3 minutes later. B) Ratio of CD45.2+ (i.v.+) to CD45.2- (i.v.−) P14 CD8 T cells in the tumor. Number of C) i.v.+ and D) i.v.− P14 CD8 T cells in the tumor 2 days after surgery. Data are representative from 2 experiments with 3 mice per group. NS = not significant. * = p<0.05; ** = p<0.01 using 1-way ANOVA corrected for multiple comparisons using Dunn’s test. Error bars represent the standard error of the mean.