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Structure and assembly of bispecific T cell engaging cytokines (BiTEokines). Schematic of drug-induced synapse formation between T cells and leukemic B cells, as well as synapse-targeted delivery of the cytokine, IL-12. Inset illustrates the modular and rapid self-assembly of CD19 × CD3 × IL12 BiTEokines via addition of human IgG to protein G-conjugated iron oxide nanoparticles and subsequent cytokine complexation. The solid beige arrow denotes cytokine release or trans-presentation.
