A, IgG4 to α-Gal (n = 65), casein (n = 50), and Ascaris (n = 65) in children from Ecuador. B, Ratio of specific IgG4/sIgE (normalized to ng/ng) in children from Ecuador who had detectable sIgE to the respective IgG4 component. C, IgG4 to α-Gal in children from Ecuador (n = 63) compared with children from the United States who were unselected for food allergy (n = 63). Values expressed as geometric mean of positives (95% CI) and compared by the Mann-Whitney U test, *P < .05, **P < .001.