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. Author manuscript; available in PMC: 2022 Feb 3.
Published in final edited form as: Sci Signal. 2021 Aug 3;14(694):eaba0245. doi: 10.1126/scisignal.aba0245

Figure 6. Differential roles for G protein and β-arrestin 1 in δOR agonist-induced ERK1/2 activation.

Figure 6.

(A to E) Schematic of the experimental conditions (A) and Western blotting analysis for ERK1/2 activation in the dorsal straitum (A), nucleus accumbens (B), dorsal hippocampus (C), amygdala (D) and ventral hippocampus (E) of WT mice 10 and 30 min after i.p. adminstration of 25 mg/kg TAN67 compared with that after saline (Con). (F to J) As described in (A to E), in β-arrestin 1 KO mice administered SNC80 (20 mg/kg) or saline. Data are from N = 6 to 7 mice (see table S5); a representative blot is beside the associated bar graph. See table S5 for one-way ANOVA and post-hoc multiple comparisons.