Table 2.
PROMIS-25 Pediatric Health-related Quality of Life domain scores and Pain Intensity throughout pediatric lymphoma treatment in Lilongwe, Malawi.
| Diagnosis | Treatment | Follow-Up | ||||
| N = 75 | N = 35 | N = 24 | ||||
| Days since Diagnosis, median [IQR] | 0 [0–0] | 113 [61–210] | 720 [486–1014] | |||
| Patient Reported, n (%) | 57 (76) | 27 (77) | 16 (67) | |||
| Caregiver Reported, n (%) | 18 (14) | 8 (13) | 8 (33) | |||
| PROMIS HRQoL Domains | Mean score (SD) | Mean score (SD) | Δ** | Mean score (SD) | Δ** | p-value |
| Mobility | 31.5 (9.1) | 49.8 (9.2) | −18.3 | 55.1 (5.6) | −5.3 | <0.001 |
| Anxiety | 61.9 (9.8) | 44.1 (10.4) | 17.8 | 41.7 (10.8) | 2.4 | <0.001 |
| Depressive Symptoms | 62.2 (6.7) | 46.7 (7.9) | 15.5 | 42.6 (8.5) | 4.1 | <0.001 |
| Fatigue | 61.7 (9.2) | 45.9 (8.3) | 15.8 | 42.6 (10.1) | 3.3 | <0.001 |
| Peer Relationships | 49.3 (7.3) | 52.6 (9.2) | −3.3 | 60.1 (3.9) | −7.5 | <0.001 |
| Pain Interference | 59.6 (9.5) | 47.2 (9.8) | 12.4 | 41.9 (8.9) | 5.3 | <0.001 |
| Pain Intensity, median [IQR] | 9 [4–10] | 1 [1–1] | — | 0 [0–0] | — | <0.001 |
*
Higher PROMIS scores for Mobility and Peer Relationships reflect better functioning and relationships; lower symptom scores reflect better symptom experiences.
**
Δ= Difference in mean domain score between timepoints. Minimally Important Difference (MID) is 2–3 points.33
PROMIS = Patient-Reported Outcomes Measurement Information System; HRQoL= Health-related quality of life, IQR = Interquartile range; SD = Standard Deviation.