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. 2021 Sep 30;2021:1552127. doi: 10.1155/2021/1552127

Figure 2.

Figure 2

Curcumin treatment reduces stroke-mediated NLRP3 inflammasome activation and pyroptosis in the ipsilateral peri-infarct regions 21 days after cerebral ischemia. (a, b) Representative western blot of NLRP3 and pyroptosis-related proteins in mice. Quantification of western blot data of NLRP3 (c), pro-caspase-1 (d), cleaved caspase-1 (e), GSDMD-FL (f), GSDMD-N (g), pro-IL-1β (h), and IL-1β (i). All the values are the mean ± SEM. ∗∗∗p < 0.001. n = 8 mice per group, 1 band/mouse. One-way ANOVA followed by Bonferroni post hoc test. GSDMD-FL denotes GSDMD-full length. GSDMD-N indicates GSDMD-N-terminal.