Table 2.

Estimated marginal means (95% CI) of the parameters of interest at baseline and their change after 90 days and 180 days of treatment.

Parameter	Baseline value	Change at 90 days	P value (90 days vs. baseline)	Change at 180 days	P value (180 days vs. baseline)
Weight (kg)	91.3 [89.5; 93.0]	-4.6 [-5.0; -4.2]	<0.0001	-7.3 [-8.0; -6.6]	<0.0001
Waist circumference (cm)	107.9 [105.9; 109.9]	-4.3 [-4.8; -3.8]	<0.0001	-7.5 [-8.2; -6.8]	<0.0001
Fasting blood glucose (mg/dL)	122.6 [120.1; 125.0]	-10.6 [-11.8; -9.3]	<0.0001	-16.3 [-17.8; -14.7]	<0.0001
HbA1c (%)	6.66 [6.55; 6.77]	-0.33 [-0.39; -0.27]	<0.0001	-0.55 [-0.62; -0.49]	<0.0001
Systolic blood pressure (mmHg)	134 [133; 136]	-4.8 [-3.7; -5.8]	<0.0001	-7.1 [-8.3; -6.0]	<0.0001
Diastolic blood pressure (mmHg)	82 [81; 83]	-2.6 [-3.2; -2.0]	<0.0001	-4.2 [-5.0; -3.5]	<0.0001
LDL cholesterol (mg/dL)	131 [127; 136]	-11.1 [-13.4; -9.0]	<0.0001	-18.2 [-21.2; -15.3]	<0.0001
HDL cholesterol (mg/dL)	49.7 [47.0; 52.3]	1.5 [-0.5; 3.5]	0.15	2.9 [0.7; 5.0]	<0.0001
Triglycerides (mg/dL)	185 [174; 196]	-23 [-34; -12]	<0.0001	-39 [-45; -32]	0.009
Fasting plasma insulin (μu/mL)	28.0 [21.8; 34.2]	-3.9 [-6.4; -1.4]	0.002	-5.7 [-8.4; -3.0]	<0.0001
HOMA-IR	8.2 [6.2; 10.2]	-1.6 [-2.3; -0.9]	<0.0001	-2.5 [-3.3; -1.7]	<0.0001
10-year cardiovascular risk (%)	6.5 [5.0; 7.9]	-1.2 [-1.5; -0.8]	<0.0001	-1.8 [-2.4; -1.2]	<0.0001