Table 4.

Univariate and multivariate Cox regression analyses of the TCGA cohort for risk score of m⁵C-related genes.

Variable	Univariate Cox regression			Multivariate Cox regression
	HR	95% CI	p value	HR	95% CI	p value
Age	1.023	1.005-1.041	0.012	1.033	1.013-1.054	0.001
Gender	0.951	0.666-1.541	0.951	1.205	0.769-1.887	0.416
Grade	2.242	1.682-2.988	<0.001	1.529	1.088-2.149	0.014
Stage	1.862	1.541-2.251	<0.001	1.435	0.843-2.441	0.183
T	1.943	1.538-2.456	<0.001	1.010	0.618-1.651	0.969
M	4.073	2.634-6.300	<0.001	1.714	0.751-3.912	0.201
N	2.932	1.516-5.668	0.001	1.593	0.768-3.304	0.211
Risk score	2.796	1.977-3.954	<0.001	1.779	1.594-2.147	0.002

HR: hazard ratio, estimated from Cox proportional hazard regression model; CI: confidence interval of the estimated HR.