Table 2.

Arachidonic acid oxidation products and their associations with Leukotriene A-4 Hydrolase, Left Ventricular Mass, and Incident Heart Failure

Metabolite	Pearson Correlation with LKHA4 (95% CI)	p-value	Beta for association with ln (LV mass) (95% CI)	p-value	HR for incident HF (95% CI)	p-value
Arachidonic acid	0.02 (−0.03, 0.07)	0.44	0.02 (0.01, 0.04)	5.0e-4	0.98 (0.76, 1.26)	0.89
5-Oxo-ETE	0.18 (0.13, 0.23)	6.4e-11	0.02 (0.00, 0.03)	0.02	1.07 (0.82, 1.39)	0.62
12-Oxo-ETE	0.20 (0.15, 0.25)	2.4e-13	0.02 (0.01, 0.03)	0.006	1.11 (0.85, 1.45)	0.44
15-Oxo-ETE	0.21 (0.16, 0.26)	1.3 e-14	0.02 (0.01, 0.03)	0.003	1.14 (0.87, 1.49)	0.35
14(15)-EET	0.26 (0.20, 0.30)	4.2e-21	0.02 (0.00, 0.03)	0.01	1.15 (0.89, 1.49)	0.29
11(12)-EET	0.27 (0.22, 0.32)	1.8e-23	0.02 (0.01, 0.03)	0.005	1.15 (0.89, 1.48)	0.28
HETE	0.27 (0.22, 0.32)	1.3e-23	0.03 (0.01, 0.04)	4.6e-5	1.17 (0.92, 1.49)	0.20

ETE = eicosatetraenoic acid, EET = epoxyeicosatrienoic acid, HETE = hydroxyeicosatetraenoic acid, CI = Confidence Interval