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. 2021 Aug 6;40(40):5913–5924. doi: 10.1038/s41388-021-01987-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The mRNAs isolated from CRC tissues and paired normal colorectal mucosa samples were assessed by dot blot analyses with an anti-m6A antibody, and methylene blue (MB) stain served as the loading control (representative images in left panel). The relative m6A content on mRNA in CRC tissues and paired normal colorectal mucosa samples were calculated (right panel, n = 15). b Scatter plot of the expression levels of WTAP, METTL3, METTL14, FTO, ALKBH5, YTHDF1, YTHDF2, IGF2BP1, IGF2BP2, and IGF2BP3 in tumor tissues relative to tumor-adjacent tissues; n = 25 tumor-normal tissue pairs for the assessment of the m6A writers, erasers, and readers listed above. The p values were determined by two-tailed t-test.