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. 2021 Aug 6;40(40):5913–5924. doi: 10.1038/s41388-021-01987-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The predominant consensus motif GGAC was detected in both the control and CRC samples by m6A-seq. b Density distribution of m6A peaks across mRNA transcripts. Portions of the 5′ untranslated region (5′ UTR), coding sequence (CDS), and 3′untranslated region (3′ UTR) were split into 100 segments, and then the percentages of m6A peaks that fell within each segment were determined. c m6A peak distribution in the 5′ UTR, start codon, CDS, stop codon or 3′ UTR across the entire set of mRNA transcripts. d Scatter plot for hypermethylated m6A peaks and hypomethylated m6A peaks in CRC tissues compared with control tissues. ‘Hypermethylated m6A peaks’, m6A peaks which are higher in CRC tissues compared to control tissues. ‘Hypomethylated m6A peaks’, m6A peaks which are lower in CRC tissues compared to control tissues. e Heatmap of 75 genes, which shows 1.5-fold m6A-mediated expression alteration in CRC tissues compared with control tissues. f, g The cluster Profiler packages identified the enriched GO and KEGG processes of 75 genes, which showed a 1.5-fold m6A-mediated expression alteration in CRC compared with the control.