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. 2021 Aug 6;40(40):5913–5924. doi: 10.1038/s41388-021-01987-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Knockdown of DEGS2 effectively impaired the subcutaneous growth of CRC tumors in nude mice (n = 5), and DEGS2-mut promoted the subcutaneous growth of CRC tumors compared to DEGS2-WT. b The liver metastasis of HCT116 cells with knockdown of DEGS2 was significantly reduced compared with the negative control group. c Graphic illustration of the mechanism by which DEGS2 m6A methylation modulates tumor ceramide metabolism and promotes CRC tumor growth.