Duplicates removed	44
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	97
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	51
Cited efficacy/tolerability articles	24
Cited articles not efficacy/tolerability	38
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were isatuximab, Sarclisa, SAR650984, multiple myeloma. Records were limited to those in English language. Searches last updated 13 July 2021