Table 1.

Examples of lectin-glycan interactions in endocytosis. The lectin, the lectin-expressing cell type, and the corresponding glycan interaction partner(s) are indicated

Lectin	Cell type/organism	Glycan/receptor	References
C-type lectins
Asialoglycoprotein receptor (ASGR)	Mainly hepatocytes	Desialylated glycoproteins that containterminal Gal or GalNAc residues on theirN-linked glycans, and also sialylatedglycoproteins with terminal Siaα2,6GalNAcand Siaα2,6Gal	Reviewed in [265, 266]
CD209/DC-SIGN	Human myeloid dendritic cells	Branched D-Man and L-Fuc motifscommon on pathogen surfaces; e.g.,mannan, Lex and Ley	Reviewed in [267]
Langerin (CD207)	Mainly Langerhans cells	Man-rich N-glycans on proteins;e.g., HIV-1 gp120 envelope protein	[268]
Man-binding lectin	Mainly hepatocytes	Man-rich N-glycans	[269]
(MBL2)
I-type lectins (they bind to non-reducing terminal sialic acids)
Sialic acid binding Ig like lectin 1 (SIGLEC1/CD169)	Macrophages	e.g., HIV-1 gp120 envelope protein	[270]
CD22	B cells	Sialoside ligands on the surface of both the same cell and adjacent cells	[271]
Galectins (they bind to β-galactoside-containing glycans)
LGALS1	e.g. T cells	e.g., PTPRC/CD45	[272]
LGALS3	e.g. fibroblasts	e.g., CD44 or glycosphingolipids	[148]
Plant lectins/toxins
Ricin (R-type lectin)	Ricinus communis	Terminal β-linked Gal- or GalNAc-containing glycans	Reviewed in [273]
Gs I-A4	Griffonia (Bandeirea) simplicifolia	Terminal α‐linked GalNAc residues, including the Tn antigen	[274]
Bacterial lectins/toxins
StxB	Shigella dysenteriae and Escherichia coli	Mainly Gb3	[136]
Cholera toxin	Vibrio cholerae	Ganglioside GM1, LeX on proteins	[275]
LecA	Pseudomonas aeruginosa	e.g., Gb3	[142]
RSL	Ralstonia solanacearum	e.g., human histo-blood group antigens	[132]
Viral lectins
VP1	Simian virus 40	Ganglioside GM1	[140]
VP1	Norovirus GII.4	ABH histo-blood group glycans on glycoproteins and GSLs	[141]