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. 2021 Jul 5;58(10):4921–4943. doi: 10.1007/s12035-021-02439-1

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Gross cerebellar structure and morphometric analysis. (A–I) Gross cerebellar structure in WT, HET, and MUT rats at postnatal day 45 (P45), 3 months, and 6 months of age is comparable. Scale bar = 1 mm for each row. (J–L) Lamination and cellular distribution in the cerebellar cortex is normal in WT, HET, and MUT rats. Six months of age shown, scale bar = 100 μm. (M–T) Morphometric analysis of cortical layer thickness in WT, HET, and MUT rats indicates no substantial reduction in any cortical layer at 3 months or 6 months, although a significant difference in Purkinje cell layer width between WT and MUT rats was noted in lobule 3 at 6 months (3 months: n = 3–5 animals/genotype. 6 months: n = 4–8 animals/genotype. Data are shown as mean ± SEM. 1-way ANOVA with Tukey’s post-hoc test. *p< 0.05). (U, V) Linear density of Purkinje cells shows no difference among WT, HET, and MUT rats (3 months: n = 5 animals/genotype. 6 months: n = 7 animals/genotype. Data are shown as mean ± SEM. 1-way ANOVA with Tukey’s post-hoc test)