Table 1.

Participant timeline

		Before hospital admission	Day 1 of hospital admission	Day 2: procedure Before surgical incision	Day 2:  procedure After surgical incision	Day 4/7
1	Approach, information provision	X
2	Informed consent	X	X
3	Inclusion in part 1 or 2	X	X
4	Pre-operative neurological examination		X
5	mTc-MEP measurements at different pEEG and MAP values			X
6	Taking blood samples for propofol blood concentrations			X
7	Collecting propofol Ce, MAP/pEEG values immediately after mTc-MEP measurements			X
8	Post-operative neurological examination					X

mTc-MEP muscle recorded transcranial electrical stimulation motor evoked potential, pEEG processed electroencephalogram, MAP mean arterial pressure