Table 3.
Confirmatory analyses with the generalized structural equation model
| Predictor | Occurrence of death (yes/no) | Time to death (year) | ||
|---|---|---|---|---|
| Unadjusted odds ratio (95% CI) | Adjusted odds ratio (95% CI) | Unadjusted hazard ratio (95% CI) | Adjusted hazard ratio (95% CI) | |
| Aetiology subtypes | ||||
| 1: iPAH | Reference | Reference | Reference | Reference |
| 2: CHD‐PAH | 0.714 (0.240–2.123) | 0.579 (0.166–2.022) | 1.271 (0.529–3.055) | 1.660 (0.616–4.474) |
| 3: CTD‐PAH | 0.977 (0.366–2.609) | 0.741 (0.158–3.473) | 0.618 (0.287–1.332) | 0.793 (0.256–2.456) |
| 4: Others | 1.4285 (0.381–5.357) | 1.149 (0.263–5.017) | 1.626 (0.616–4.288) | 1.773 (0.580–5.420) |
| Age | ||||
| 1: < =53 years | Reference | Reference | Reference | Reference |
| 2: >53 years | 2.496 (1.105–5.639)* | 2.342 (0.909–6.034) | 2.973 (1.524–5.799) | 2.242 (1.122–5.218) |
| Incident | ||||
| 1: Incident | Reference | Reference | Reference | Reference |
| 2: Prevalent | 1.365 (0.617–3.018) | 2.177 (0.616–7.685) | 0.760 (0.407–1.420) | 0.899 (0.364–2.221) |
| BMI category | ||||
| 1: Normal | Reference | Reference | Reference | Reference |
| 2: Underweight | 1.990 (0.618–6.415) | 2.412 (0.600–9.696) | 1.833 (0.777–4.327) | 2.670 (0.917–7.772) |
| 3: Overweight/Obese | 1.121 (0.460–2.730) | 0.945 (0.334–2.672) | 1.089 (0.534–2.218) | 1.106 (0.485–2.526) |
| WHO functional class | ||||
| 1: I/II | Reference | Reference | Reference | Reference |
| 2: III/IV | 1.420 (0.561–3.597) | 1.678 (0.597–4.714) | 1.195 (0.593–2.406) | 1.779 (0.792–3.998) |
| Therapy | ||||
| 0: No | Reference | Reference | Reference | Reference |
| 1: Mono | 0.659 (0.152–2.860) | 1.004 (0.176–5.710) | 0.704 (0.242–2.047) | 0.531 (0.141–2.001) |
| 2: Combination | 0.625 (0.127–3.081) | 1.293 (0.201–8.320) | 0.610 (0.189–1.967) | 0.637 (0.162–2.503) |
| PAPi | ||||
| 1: > =5.3 | Reference | Reference | Reference | Reference |
| 2: <5.3 | 2.496 (1.105–5.639)* | 2.976 (1.160–7.634)* | 2.458 (1.280–4.718)* | 2.229 (1.053–4.719)* |
BMI, body mass index; CHD‐PAH, congenital heart disease associated pulmonary arterial; CI, confidence interval; CTD‐PAH, connective tissue disease associated pulmonary arterial hypertension; iPAH, idiopathic pulmonary arterial hypertension; PAPi, pulmonary artery pulsatility index; WHO, World Health Organization.
*
Statistically significant at 5%.