TABLE 1.
Baseline characteristics according to treatment strategy
| Characteristic (No. = 228,753) | No dose change (No. = 93,793) | Dose decrease (No. = 72,672) | Dose increase (No. = 62,288) |
|---|---|---|---|
| Age, mean (SD), years | 74.9 (7.4) | 75.6 (7.6) | 75.2 (7.5) |
| Male | 92,051 (98.1) | 71,380 (98.2) | 61,242 (98.3) |
| Baseline SBP, mean (SD), mmHg | 117.5 (7.1) | 115.6 (8.3) | 116.9 (7.5) |
| ≤110.0 mmHg | 14,775 (15.7) | 17,202 (23.7) | 11,329 (18.2) |
| 110.5–120.0 mmHg | 41,238 (44.0) | 31,225 (43.0) | 27,113 (43.5) |
| 120.5–129.0 mmHg | 37,780 (40.3) | 24,245 (33.3) | 23,846 (38.3) |
| Chronic conditions | |||
| Number, mean (SD) | 3.0 (3.1) | 4.3 (3.6) | 3.7 (3.5) |
| Multimorbidity a | 70,850 (75.5) | 62,013 (85.3) | 50,573 (81.2) |
| Vascular disorder b | 25,602 (27.3) | 29,503 (40.6) | 23,091 (37.1) |
| Heart failure or valve disorder | 11,500 (12.3) | 17,295 (23.8) | 13,681 (22.0) |
| Diabetes mellitus, type II | 29,341 (31.3) | 28,859 (39.7) | 23,689 (38.0) |
| Fall risk c | 15,788 (16.8) | 18,089 (24.9) | 13,196 (21.2) |
| Antihypertensive medication | |||
| Total dose, mean (SD), HDD | 2.2 (1.8) | 2.9 (2.2) | 2.3 (1.9) |
| Medication count, mean (SD) | 2.2 (1.1) | 2.8 (1.3) | 2.6 (1.2) |
Note: Dichotomous variables are presented as N (%), and continuous variables as mean with standard deviation.
Abbreviations: HDD, hypertension daily dose; No., number.
a
Hypertension with ≥1 additional chronic condition.
b
Cardiac, peripheral, and/or cerebral vascular disorder.
c
Fall risk included Parkinson's disease, peripheral neuropathy, ataxia, vertigo/dizziness, orthostatic hypotension, walking difficulty/gait abnormality/lack of coordination, muscle weakness, syncope, history of fall (ICD‐9 codes: 340–342.91, 356.XX, 357.XX, 386.XX, 438.2–438.22, 438.40–438.42, 438.84, 438.85, 458.0, 719.7, 728.87, 780.2, 780.4, 781.1, 781.2, 781.3, V15.88).