TABLE 2.
Adjusted outcome risks according to treatment strategy (No. = 228,753 patients)
| Adjusted absolute risks (95% CI), % a | ||
|---|---|---|
| Outcomes | Dose change | Medication count change |
| Composite outcome | ||
| Stable treatment b | 14.8 (14.6 to 15.0) | 16.2 (16.0 to 16.3) |
| Deintensification | 18.3 (18.1 to 18.6) | 19.8 (19.4 to 20.3) |
| Intensification | 18.7 (18.4 to 19.0) | 22.1 (21.5 to 22.7) |
| Cardiovascular event | ||
| Stable treatment b | 9.1 (8.9 to 9.2) | 10.5 (10.4 to 10.6) |
| Deintensification | 12.3 (12.0 to 12.5) | 13.4 (13.1 to 13.8) |
| Intensification | 13.2 (12.9 to 13.4) | 16.7 (16.2 to 17.3) |
| Syncope | ||
| Stable treatment b | 1.3 (1.2 to 1.3) | 1.4 (1.4 to 1.5) |
| Deintensification | 1.7 (1.6 to 1.8) | 1.8 (1.6 to 1.9) |
| Intensification | 1.6 (1.5 to 1.7) | 1.8 (1.6 to 2.0) |
| Fall injury | ||
| Stable treatment b | 8.3 (8.1 to 8.5) | 8.7 (8.6 to 8.8) |
| Deintensification | 9.7 (9.5 to 9.9) | 10.2 (9.9 to 10.5) |
| Intensification | 9.1 (8.9 to 9.4) | 9.9 (9.4 to 10.4) |
Abbreviation: CI, confidence interval.
a
Based on logistic regression model weighted to account for missing outcome. The model included interaction terms between age and systolic blood pressure and between systolic blood pressure and treatment strategy, and was also adjusted for baseline antihypertensive medication dose and for chronic conditions (Table S1).
b
Reference group, defined as no dose or medication count change, respectively, is displayed in italic to facilitate reading.