Table 4:

Hazard Ratios for Death within 1 Year^* after Hospital Discharge based on Neurohormonal Drug Exposure, Stratified by Age, 2008–2015^†

	Hazard Ratio	95% Confidence Interval	P-Value
Beta Blocker Exposure
Age 66–74
1–80 PDC	0.46	0.44, 0.49	<0.001
80+ PDC	0.37	0.35, 0.39	<0.001
Age 75–84
1–80 PDC	0.49	0.47, 0.51	<0.001
80+ PDC	0.39	0.37, 0.40	<0.001
Age 85+
1–80 PDC	0.56	0.54, 0.58	<0.001
80+ PDC	0.43	0.42, 0.45	<0.001
ACEi/ARB/ARNI Exposure
Age 66–74
1–80 PDC	0.43	0.42, 0.45	<0.001
80+ PDC	0.39	0.37, 0.41	<0.001
Age 75–84
1–80 PDC	0.45	0.44, 0.47	<0.001
80+ PDC	0.38	0.37, 0.40	<0.001
Age 85+
1–80 PDC	0.53	0.52, 0.55	<0.001
80+ PDC	0.45	0.43, 0.47	<0.001

PDC is proportion of days covered which is the number of days “covered by drug” based on Part D prescription fills over the number of days in the follow-up period

No beta-blocker exposure and no ACEi/ARB exposure is the reference group.

^*Conditional on survival to 30 days after discharge

^†Errors are clustered at the hospital referral region level.