Table 3.
Histopathology result at one-year follow-up correlated with sequential high-risk HPV screening results among 236 women living with HIV
| Histopathology result at one-year follow-up | High-risk HPV + / high-risk HPV + n = 31a |
High-risk HPV + / high-risk HPV − n = 36b |
High-risk HPV − / high-risk HPV + n = 15c |
High-risk HPV − / high-risk HPV − n = 154d |
|---|---|---|---|---|
| Benign | 12 (39) | 6 (17) | 6 (40) | 0 (0) |
| CIN1 | 9 (29) | 1 (3) | 1 (7) | 1 (1) |
| CIN2 | 3 (10) | 2 (6) | 2 (13) | 1 (1) |
| CIN3 | 7 (23) | 1 (3) | 6 (40) | 0 (0) |
Note: Excludes the 1 participant who was not eligible for colposcopy at one year due to pregnancy
Of the cases of CIN2 and CIN3 in this category, four had persistent HPV16 or 18, four had persistent other high-risk HPV, and two had cleared HPV16 but acquired other high-risk HPV at follow-up.
Only participants with indications underwent colposcopy according to the study protocol or clinical guidelines. These participants included: 8 who had CIN2 or higher at baseline, 1 with persistent low-grade cytology, and 1 with postmenopausal bleeding. The three cases of CIN2 or higher all had other high-risk HPV at baseline.
Of the cases of CIN2 and CIN3 in this category, seven were associated with other high-risk HPV and one with co-infection with HPV16 and HPV18.
Only women with indications underwent colposcopy. These participants included: one who had persistent low-grade cytology and one who had an abnormal cervical examination.