Table 5.

Binding affinity for compounds 20–23. (IC₅₀ values in μM).^[a]

Compound	CBX1	CBX2	CBX4	CBX6	CBX7	CBX8
20	> 300	N.T.[b]	N.T.[b]	2.8	40	7.5
21	N.T.[b]	246	330	7.5	268	2.2
22	> 500	6.8	9.8	0.2	3.6	0.2[c]
23	N.T.[b]	21[d]	18[d]	2.2	5.4	1.0

^[a]Competitive FP assays performed in triplicate unless stated otherwise. Raw data and asymmetric 95% confidence intervals are reported in SI.

^[b]Not tested

^[c]Estimated value because IC₅₀ is outside of linear range of assay.^[22–23]

^[d]Shallow FP curve. See SI.