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. Author manuscript; available in PMC: 2021 Nov 27.
Published in final edited form as: Nat Biomed Eng. 2021 May 27;5(9):1048–1058. doi: 10.1038/s41551-021-00728-7

Figure 1 |. Synthesis of the reduction-responsive polymer and formation of NPs.

Figure 1 |

a, Synthesis of poly (CHTA-co-HD)-PEG. b, Structures of OxaPt(IV) and 56MESS. c, d, Formation of NPs by nanoprecipitation. c, Formation of NP-OxaPt(IV). d, Preparation of NP-56MESS. e, A schematic illustrating that oxaliplatin and 56MESS induce cell death after GSH-mediated drug release. ER, endoplasmic reticulum; rRNA, ribosomal RNA.