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. Author manuscript; available in PMC: 2021 Nov 27.
Published in final edited form as: Nat Biomed Eng. 2021 May 27;5(9):1048–1058. doi: 10.1038/s41551-021-00728-7

Figure 7 |. Analysis of the metabolic pathways in LN229-TS cells treated with TMZ, 56MESS and NP-56MESS.

Figure 7 |

a, Comparison between the PBS group and the TMZ group (PBS versus TMZ). The top five enriched pathways are (1) histidine metabolism (P = 0.18), (2) purine metabolism, (3) thiamine metabolism, (4) lysine degradation and (5) glutathione metabolism. b, PBS versus 56MESS. Top pathways: (1) histidine metabolism (*P = 0.049), (2) arginine and proline metabolism (P = 0.05), (3) nitrogen metabolism and (4) alanine, aspartate, glutamate metabolism. c, TMZ versus 56MESS. Top pathways: (1) histidine metabolism (*P = 0.01), (2) purine metabolism (*P = 0.04) and (3) nitrogen metabolism (P = 0.16). d, 56MESS versus NP-56MESS. Top pathways: (1) purine metabolism (P = 0.2), (2) glycerophospholipid and (3) tryptophan metabolism. The colour and size of each circle is based on P values from enrichment analysis and pathway impact values from topology analysis, respectively. n=3, biological replicates.