Fig. 6. A functional dim2 gene is associated with less structural variation and less effects of TE on deletions.

Differences in the rate of structural variants in wild type strains that do (Zt10) or do not (IPO323 and Zt05) contain a functional dim2 gene. a Rate of base substitution mutation and structural variants, and chromosome losses and duplications in the evolved replicated MA lines. The significantly increased base substitution mutation rate in Zt10 (functional dim2) is associated with significantly lower rates of deletions, insertions, and duplications, and lower rates for chromosome losses and duplications. b Relative frequency for the start and end positions of deletions being associated with TEs is lower for deletions in Zt10 compared to deletions in IPO323 and Zt05, which lack a functional copy of the dim2 gene. Categorized p-values of a FDR-adjusted two-sided χ²-test or b two-sided Fisher’s exact test are depicted (*p < 0.05, **p < 0.005, ***p < 0.0005, ns = not significant at α = 0.05). The exact p-values for of all pairwise comparisons are provided in Supplementary Data 1. a Data were pooled for all replicated MA lines of each strain (n = 40 independently evolved MA lines per strain) and is presented as mean values. Error bars depict 95% Poisson confidence intervals.