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. 2021 Oct 7;11:19977. doi: 10.1038/s41598-021-99482-8

Table 4.

Cox proportional hazard models obtained by means of stepwise regression or backward elimination (maximum of 50 iterations).

Stepwise regression model
− 2LogL AIC SBC R2
25.98 29.98 30.77 0.77
Variable Coefficient SE χ2 p − 95% CI 95% CI HR − 95% CI HR 95% CI HR
SOFA (1) − 0.5083 0.1883 7.2882 0.0069 − 0.8773 − 0.1393 0.6015 0.4159 0.8700
Glutamine (Gln) − 0.0083 0.0040 4.4167 0.0356 − 0.0161 − 0.0006 0.9917 0.9840 0.9994
Backward elimination model
− 2LogL AIC SBC R2
15.04 25.04 27.03 0.91
Variable Coefficient SE χ2 p − 95% CI 95% CI HR − 95% CI HR 95% CI HR
APACHE II 0.1977 0.1160 2.9022 0.0885 − 0.0298 0.4251 1.2186 0.9707 1.5297
SOFA − 1.3534 0.5261 6.6181 0.0101 − 2.3846 − 0.3223 0.2583 0.0921 0.7245
Glutamine (Gln) − 0.0140 0.0068 4.2281 0.0398 − 0.0273 − 0.0007 0.9861 0.9731 0.9993
Septic shock: NO − 2.2801 0.9862 5.3452 0.0208 − 4.2130 − 0.3472 0.0105 0.0002 0.4994
Sex: MALE 1.7225 0.9765 3.1112 0.0778 − 0.1915 3.6364 31.3410 0.6818 1440.6253

P-values < 0.05 and their corresponding hazard ratios (HR) are marked in bold. AIC, Akaike information criterion; SBC, Schwarz bayesian criterion; SE, standard error; HR, hazard ratio; CI, confidence interval, SOFA, sequential organ failure assessment; Gln, glutamine.