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. 2021 Oct 7;12:5890. doi: 10.1038/s41467-021-25957-x
GqRg×m Input query gene expression matrix, prior to scaling.
GqsRg×m Query gene expression matrix, scaled by reference gene means μ and standard deviations σ.
Xq{0,1}c×m Design matrix assigning query cells (cols) to query batches (rows).
Zq=ΣqVqTRd×m Query cell locations in original (pre-harmonized) reference PC embedding.
Z^qRd×m Approximate query cell locations in integrated embedding (hPC space). Output of Symphony reference mapping.
Rq[0,1]k×m Soft cluster assignment of query cells (cols) to clusters (rows). Each column is a probability distribution that sums to 1.
BqRk×(1+c)×d 3D tensor of the estimated parameters (betas and intercepts) of the linear mixture model for each of k clusters.